Author

Xuexiang Han

University of PennsylvaniaORCID 0000-0003-0011-5222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1 Approach:statistical model· 1

Frequent Co-Authors

Michael J. MitchelliD· 3 shared Drew WeissmaniD· 2 shared Junchao XuiD· 2 shared Lulu XueiD· 2 shared Adele S. RicciardiiD· 1 shared Ajay S. ThatteiD· 1 shared Alex G. HamiltoniD· 1 shared Amanda M. MurrayiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBioengineering

Michael J. MitchellORCID

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3 papers

Recent·Most cited

BioengineeringProceedings of the National Academy of SciencesPeer-reviewedMay 26, 2026

Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo

Xuexiang Han, Ying Xu, Adele S. Ricciardi…·Michael J. Mitchell

This study develops a combinatorial chemistry approach to create biodegradable ionizable lipids for efficient mRNA delivery and gene editing in vivo.

13 citationstop 1%

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Cancer BiologyDevelopmental CellPeer-reviewedMar 23, 2026

Solid tumor growth depends on an intricate equilibrium of malignant cell states

Stefan R. Torborg, Jung Yun Kim, Anupriya Singhal…·Tuomas Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

6 citations

humanstatistical model

𝕏 PostBluesky

BioengineeringAdvanced MaterialsPeer-reviewedJan 28, 2026

High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy

Alex G. Hamilton, Ajay S. Thatte, Junchao Xu…·Michael J. Mitchell

15 citationstop 1%

𝕏 PostBluesky