Adele S. Ricciardi

This study develops a combinatorial chemistry approach to create biodegradable ionizable lipids for efficient mRNA delivery and gene editing in vivo.

This paper presents an automated microfluidic platform for generating large, precisely-defined lipid nanoparticle libraries and evaluates their physicochemical and transfection properties.

This study develops anti-CD38 lipid nanoparticles for targeted mRNA delivery to multiple myeloma cells, improving tumor targeting and reducing hepatic accumulation.

This study uses biophysical methods to characterize lipid nanoparticle properties and predict their transfection efficiency.

This study demonstrates systemic in utero gene editing using PNAs in nanoparticles to correct CFTR mutations in multiple organs of CF mice, showing sustained CFTR activity without off-target effects.