Author

Christine E. Cucinotta

Fred Hutch Cancer CenterORCID 0000-0002-9644-3126Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Rachel Dell· 2 shared Toshio TsukiyamaiD· 2 shared A Elizabeth HildrethiD· 1 shared Brendan M. McShaneiD· 1 shared Karen M. ArndtiD· 1 shared Keean C. A. BracerosiD· 1 shared Kris G. AlavattamiD· 1 shared Margaret K. ShirraiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 11 mutual co-author links

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2 shared papersMolecular Biology

Rachel Dell

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3 papers

Recent·Most cited

Sir2 is required for the quiescence-specific condensed three-dimensional chromatin structure of rDNA

Christine E. Cucinotta, Rachel Dell, Kris G. Alavattam, Toshio Tsukiyama

This study identifies a unique condensed 3D chromatin structure of rDNA in quiescent yeast cells and shows that Sir2 is essential for maintaining this structure and proper quiescence transitions.

bioRxiv · Dec 12, 2024 · PreprintMolecular Biology

RSC primes the quiescent genome for hypertranscription upon cell cycle re-entry

Christine E. Cucinotta, Rachel Dell, Keean C. A. Braceros, Toshio Tsukiyama

This study shows that RSC primes quiescent chromatin for rapid transcription upon cell cycle re-entry by pre-binding target genes and facilitating Pol II loading and transcription.

eLife · May 27, 2021Peer-reviewedMolecular Biology

The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

Christine E. Cucinotta, A Elizabeth Hildreth, Brendan M. McShane, Margaret K. Shirra, Karen M. Arndt

The paper identifies direct interactions between the nucleosome acidic patch and Paf1 and FACT complex subunits, showing their role in chromatin architecture and transcription elongation.

Nucleic Acids Research · Jun 11, 2019Peer-reviewedMolecular Biology