Synthesizing Mechanistic Hypotheses from Single-Cell Omics via Discretized Feature Attribution and Empirical Language Model Grounding
Jerry Chen, Yunqi Hong, Alexandra G. Bermudez, Jimmy Kuang‐Hsien Hu, Cho-Jui Hsieh, Neil Y. C. Lin
This paper introduces a framework to convert continuous neural network attributions into testable biological hypotheses using decision trees and language models, validated on single-cell omics data.
bioRxiv · Jul 10, 2026 · PreprintSystems Biology