Philippe Ravassard

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

The paper shows that the UPRER coordinates mitochondrial stress responses in human dopaminergic neurons, including mitophagy and lncRNA expression, and identifies a lncRNA involved in translation resumption.

This study identifies Tensin3 as a critical regulator of oligodendrocyte differentiation by mediating integrin-β1 survival signaling during morphological changes.

This study identifies HASTER, a lncRNA that stabilizes HNF1A expression through cis-regulatory mechanisms, and shows its disruption leads to diabetes.

The paper shows that a mutation associated with neonatal diabetes disrupts chromatin activation of the insulin gene in human cells.

The paper links diabetes-associated enhancers with their target genes using 3D chromatin architecture in human pancreatic islets, revealing genetic variants that impact insulin secretion heritability.

This study shows that knocking down GPR88 in the associative striatum of a rat PD model reduces psychiatric symptoms by modulating Rgs4 and ΔFosB.

This study identifies β cell-specific lncRNAs that regulate transcriptional networks and show dysregulation in type 2 diabetes.