Discovery of Epigenetically Silenced Tumor Suppressor Genes in Aggressive Breast Cancer Through a Computational Approach
Anne-Laure Vitte, Florent Chuffart, Emmanuelle Jacquet, Eleni Nika, Mireille Mousseau, Ina Jung, Séverine Tabone‐Eglinger, Thomas Bachelot, Sophie Rousseaux, Saadi Khochbin, Ekaterina Bourova-Flin
The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.
NAR Cancer · Apr 2, 2025Peer-reviewedBioinformatics