Ekaterina Bourova-Flin

ATAD2 mediates chromatin-bound histone chaperone turnover

This study shows ATAD2 regulates chromatin-bound histone chaperone turnover, affecting H3.3 localization and gene transcription during spermatogenesis.

Discovery of Epigenetically Silenced Tumor Suppressor Genes in Aggressive Breast Cancer Through a Computational Approach

The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.

Disruption of the epigenetic regulator BAP1 drives chromatin remodeling leading to the emergence of cells with breast cancer stem cell properties and aberrant glycosylation.

This study shows that disrupting BAP1, an epigenetic regulator, causes chromatin remodeling and leads to breast cancer stem cell-like properties and altered glycosylation.

Nucleoside Diphosphate Kinases 1 and 2 regulate a protective liver response to a high-fat diet

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.

Maternal exposure to cigarette smoking induces immediate and durable changes in placental DNA methylation affecting enhancer and imprinting control regions

This study identifies 344 differentially methylated regions in placental DNA linked to maternal smoking, including reversible and persistent changes in former smokers.