Author

Anne-Laure Vitte

Centre National de la Recherche ScientifiqueORCID 0000-0002-8091-7673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Ekaterina Bourova-FliniD· 2 shared Florent ChuffartiD· 2 shared Saadi KhochbiniD· 2 shared Sophie RousseauxiD· 2 shared Annie AdraitiD· 1 shared Azadeh HajmirzaiD· 1 shared Carlo PetosaiD· 1 shared Cyrille Y. BottéiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Ekaterina Bourova-FlinORCID

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2 papers

Recent·Most cited

Discovery of Epigenetically Silenced Tumor Suppressor Genes in Aggressive Breast Cancer Through a Computational Approach

Anne-Laure Vitte, Florent Chuffart, Emmanuelle Jacquet, Eleni Nika, Mireille Mousseau, Ina Jung, Séverine Tabone‐Eglinger, Thomas Bachelot, Sophie Rousseaux, Saadi Khochbin, Ekaterina Bourova-Flin

The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.

NAR Cancer · Apr 2, 2025Peer-reviewedBioinformatics

Nucleoside Diphosphate Kinases 1 and 2 regulate a protective liver response to a high-fat diet

Domenico Iuso, I. Garcia-Saez, Yohann Couté, Yoshiki Yamaryo‐Botté, Elisabetta Boeri Erba, Annie Adrait, Nour Zeaiter, Małgorzata Tokarska-Schlattner, Zuzana Macek Jílková, Fayçal Boussouar, Sophie Barral, Luca Signor, Karine Couturier, Azadeh Hajmirza, Florent Chuffart, , Saadi Khochbin

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.

Science Advances · Sep 6, 2023Peer-reviewedMolecular Biology