Saadi Khochbin

This study shows ATAD2 regulates chromatin-bound histone chaperone turnover, affecting H3.3 localization and gene transcription during spermatogenesis.

The paper shows that species-specific PRM1 cysteine residues determine nuclear shape and histone retention in sperm by analyzing mutant mice.

The paper investigates how BRD4-NUT condensates physically constrain chromatin movement in human cells through liquid-like dynamics and nucleosome crosslinking.

The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.

This study shows that disrupting BAP1, an epigenetic regulator, causes chromatin remodeling and leads to breast cancer stem cell-like properties and altered glycosylation.

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.

This study identifies 344 differentially methylated regions in placental DNA linked to maternal smoking, including reversible and persistent changes in former smokers.