BioinformaticsNAR CancerPeer-reviewed
Discovery of Epigenetically Silenced Tumor Suppressor Genes in Aggressive Breast Cancer Through a Computational Approach
Anne-Laure Vitte, Florent Chuffart, Emmanuelle Jacquet…·Ekaterina Bourova-Flin
The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.
3 citations