Author

Thomas Bachelot

Centre Léon BérardORCID 0000-0002-0866-9484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Séverine Tabone‐EglingeriD· 2 shared Alain Roger ThierryiD· 1 shared Anne-Laure VitteiD· 1 shared Benjamin BesseiD· 1 shared Benoît Roch· 1 shared Ekaterina Bourova-FliniD· 1 shared Ekaterina PisarevaiD· 1 shared Eleni NikaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Séverine Tabone‐EglingerORCID

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2 papers

Recent·Most cited

Single- and double-strand circulating DNA fragmentomics for enhanced cancer detection performance

Ekaterina Pisareva, Marianne Richaud, Séverine Tabone‐Eglinger, Thomas Bachelot, Benoît Roch, Thibault Mazard, William Jacot, Véronique Pezzella, Benjamin Besse, Fabrice André, Marc Ychou, Jacques Colinge, Alain Roger Thierry

This paper develops a method using circulating DNA fragment end motifs and machine learning to detect cancer with high accuracy across multiple cancer types.

bioRxiv · Sep 17, 2025 · PreprintGenomics

Discovery of Epigenetically Silenced Tumor Suppressor Genes in Aggressive Breast Cancer Through a Computational Approach

Anne-Laure Vitte, Florent Chuffart, Emmanuelle Jacquet, Eleni Nika, Mireille Mousseau, Ina Jung, Séverine Tabone‐Eglinger, Thomas Bachelot, Sophie Rousseaux, Saadi Khochbin, Ekaterina Bourova-Flin

The paper identifies 154 genes downregulated via DNMT3B-driven hypermethylation in aggressive breast cancer, including GATA3, which is inactivated through either mutations or hypermethylation, both linked to poor prognosis.

NAR Cancer · Apr 2, 2025Peer-reviewedBioinformatics