Eric Burguière

Expression profiling of the learning striatum

The paper profiles the transcriptome of striatal subregions in mice during learning stages to identify molecular changes and provides a web tool for exploring the data.

Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviors

The paper shows that activating striatal parvalbumin interneurons at the start of compulsive behaviors reduces these behaviors efficiently using closed-loop optogenetics.

A cross-species assessment of behavioral flexibility in compulsive disorders

This study assesses behavioral flexibility in compulsive disorders across species, finding no consistent link between compulsive behaviors and reduced flexibility, but identifying a subgroup with increased response lability.

Reduced axon caliber in the associative striatum of the Sapap3 knockout mouse

The study finds reduced axon caliber in the associative striatum of Sapap3-KO mice, affecting signal conduction but not the sensorimotor striatum.

Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors.

This paper re-evaluates the Sapap3-KO mouse model, revealing a spectrum of pathological repetitive behaviors beyond compulsivity, including tic-like movements and aberrant scratching.

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human

This study identifies CalDAG-GEFI mutations causing psychomotor symptoms and bleeding in multiple species, revealing conserved signaling deficits in striatal function.

Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels

This study examines Foxp2 expression patterns in a humanized mouse model and finds region-specific shifts in striatal expression levels associated with behavioral changes.