Jack M. O’Shea

The paper designs periplasmic binding protein biosensors using molecular dynamics and residue contact analysis, identifying both known and novel insertion sites for effector proteins.

This study uses genetic code expansion and optical targeting in C. elegans to selectively activate gene expression in specific neurons and analyze their role in behavior.

This paper develops photocaged nanobodies for in vivo applications using genetic code expansion and computational methods to control protein interactions with light.

The paper identifies a novel mechanism of sexual dimorphism in the nervous system through direct glia-to-neuron transdifferentiation during sexual maturation in C. elegans.