Steven J. Cook

The paper compares terminal and subtype selectors in two nematode species to study neuronal evolution over 200 million years, finding conservation and novelty in regulatory programs.

The paper compares whole-brain neural activity between sexes of C. elegans in response to various chemical stimuli, finding widespread sexual dimorphism in sensory neurons.

The paper characterizes the 3D organization of large axons in human white matter, revealing distinct architectural patterns across different brain regions.

The paper characterizes monoaminergic neurons in Pristionchus pacificus, identifying conserved and novel patterns of neurotransmitter expression and function in behaviors like host-finding and dispersal.

The paper compares the nervous systems of two nematode species to identify patterns of evolutionary change in their connectomes.

The paper shows that nematodes use left/right asymmetric neurons to process salt cues, revealing evolutionary changes in gustatory systems despite limited neuron numbers.

The paper shows that Caenorhabditis elegans restructures an asymmetric neural circuit during associative learning through paracrine insulin signaling.

The paper evaluates C. elegans connectomes to assess whether neuronal adjacency predicts synaptic connectivity, supporting Peters rule over the lock-and-key model.

The paper investigates the role of homeobox genes in neuronal identity specification in C. elegans, finding that 111 of 118 neuron classes require homeobox genes for proper differentiation.

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

The paper identifies a novel mechanism of sexual dimorphism in the nervous system through direct glia-to-neuron transdifferentiation during sexual maturation in C. elegans.

The paper presents a complete structure-function model of the C. elegans nerve ring by integrating volumetric reconstructions with synaptic and gap junctional connectomes, revealing modular organization and a reference core circuit.

The paper re-evaluates the connectome of the C. elegans pharyngeal nervous system using serial EM reconstruction, revealing a more detailed structure and sensory-motor characteristics.

The paper compares the neuroanatomy and connectivity of the chemosensory system in two nematode species, finding conservation in neuronal number and position but divergence in ciliary morphology and synaptic wiring.

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.

The paper reconstructs the C. elegans nerve ring at two time points and identifies three levels of wiring specificity, suggesting non-spatial factors contribute to synaptic and subcellular specificity.