Roger W. Craig

The Dilated Cardiomyopathy E525K Mutation Stabilizes the Cardiac Myosin Interacting-Heads Motif While Activating the Isolated Motor Domain

This study investigates how the E525K mutation in cardiac myosin affects its structure and function by analyzing conformational changes using cryo-EM and MD simulations.

Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy

The paper maps missense variants in cardiomyopathy genes to a cryo-EM model of the cardiac thick filament, identifying molecular interfaces critical for disease pathogenesis.

Cryo-EM Reveals How Cardiomyopathy Therapeutic Drugs Modulate the Myosin Motors of the Heart

The paper uses cryo-EM to determine the structures of myosin bound to two cardiomyopathy drugs, revealing how they modulate myosin conformation to control cardiac contractility.

QuickStainer: a rapid negative staining device for improved preservation of molecular structure

QuickStainer improves preservation of labile macromolecules by rapidly staining samples with minimal incubation time on the carbon grid.