Author

Ruchi Gautam

The University of Texas at San Antonio Health Science CenterORCID 0009-0002-6632-8917Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Assay:electronic health records· 1 Research Focus:imputation· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Arun Kumar SomavarapuiD· 2 shared Christopher M. YengoiD· 2 shared Jinghua GeiD· 2 shared Raúl PadróniD· 2 shared Roger W. CraigiD· 2 shared Aditya Prasad Patra· 1 shared Debabrata DuttaiD· 1 shared Kalen Z. RobesoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Arun Kumar SomavarapuORCID

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2 papers

Recent·Most cited

The Dilated Cardiomyopathy E525K Mutation Stabilizes the Cardiac Myosin Interacting-Heads Motif While Activating the Isolated Motor Domain

Ruchi Gautam, Arun Kumar Somavarapu, Kalen Z. Robeson, Matthew Carter Childers, Michael Regnier, Jinghua Ge, Christopher M. Yengo, Roger W. Craig, Raúl Padrón

This study investigates how the E525K mutation in cardiac myosin affects its structure and function by analyzing conformational changes using cryo-EM and MD simulations.

bioRxiv · Oct 8, 2026 · PreprintBiophysics

QuickStainer: a rapid negative staining device for improved preservation of molecular structure

Vu Nguyen, Ruchi Gautam, Arun Kumar Somavarapu, Debabrata Dutta, Aditya Prasad Patra, Jinghua Ge, Christopher M. Yengo, Raúl Padrón, Roger W. Craig

QuickStainer improves preservation of labile macromolecules by rapidly staining samples with minimal incubation time on the carbon grid.

Journal of Structural Biology · Feb 21, 2026Peer-reviewedBiophysics