Arun Kumar Somavarapu

This study investigates how the E525K mutation in cardiac myosin affects its structure and function by analyzing conformational changes using cryo-EM and MD simulations.

The paper uses cryo-EM to determine the structures of myosin bound to two cardiomyopathy drugs, revealing how they modulate myosin conformation to control cardiac contractility.

QuickStainer improves preservation of labile macromolecules by rapidly staining samples with minimal incubation time on the carbon grid.