Raúl Padrón

This study investigates how the E525K mutation in cardiac myosin affects its structure and function by analyzing conformational changes using cryo-EM and MD simulations.

The paper maps missense variants in cardiomyopathy genes to a cryo-EM model of the cardiac thick filament, identifying molecular interfaces critical for disease pathogenesis.

The paper uses cryo-EM to determine the structures of myosin bound to two cardiomyopathy drugs, revealing how they modulate myosin conformation to control cardiac contractility.

QuickStainer improves preservation of labile macromolecules by rapidly staining samples with minimal incubation time on the carbon grid.

The paper uses an atomic model of the human cardiac thick filament to compute contributions of different components to X-ray diffraction patterns, confirming some interpretations and contradicting others.