This study identifies Putrescine-responsive feedback regulation of ADC2 in Arabidopsis mediated by 5'-UTR elements, showing translational repression and its role in Put homeostasis.

bioRxiv · Nov 2, 2026 · PreprintPlant Biology

Genome-wide identification of Arabidopsis non-AUG-initiated upstream ORFs with evolutionarily conserved regulatory sequences that control protein expression levels

Yuta Hiragori, Hiro Takahashi, Taihei Karino, Atsushi Kaido, Noriya Hayashi, Shun Sasaki, Kodai Nakao, Taichiro Motomura, Yui Yamashita, Satoshi Naito, Hitoshi Onouchi

The paper identifies four novel non-AUG-initiated upstream ORFs in Arabidopsis that regulate protein expression levels through conserved sequences.

Plant Molecular Biology · Aug 31, 2022Peer-reviewedGenomics

Comprehensive genome-wide identification of angiosperm upstream ORFs with peptide sequences conserved in various taxonomic ranges using a novel pipeline, ESUCA

Hiro Takahashi, Noriya Hayashi, Yuta Hiragori, Shun Sasaki, Taichiro Motomura, Yui Yamashita, Satoshi Naito, Anna Takahashi, Kazuyuki Fuse, Kenji Satou, Toshinori Endo, Shoko Kojima, Hitoshi Onouchi

The paper introduces a pipeline called ESUCA to identify conserved upstream ORFs (CPuORFs) across multiple plant species and finds that many of these CPuORFs are functionally conserved.

BMC Genomics · Mar 30, 2020Peer-reviewedBioinformatics