Arabidopsis epigenetic factor AS2 attenuates nucleolar stress by camptothecin and establishes leaf polarity by repressing a CDK inhibitor
Ayami Nakagawa, Hidekazu Iwakawa, Hiro Takahashi, Simon Vial-Pradel, Mari Takahashi, Kazuomi Ohga, Takuma Ito, Motoki Tamai, Eri Takada, Sumie Keta, Nanako Ishibashi, Sayuri Ando, Iwai Ohbayashi, Masaki A. Ito, Mami Yamazaki, , Chiyoko Machida
The paper identifies camptothecin as a chemical modulator of AS2 function in Arabidopsis, showing its role in leaf polarity by regulating nucleolar stress and CDK inhibitor expression.
bioRxiv · Sep 23, 2025 · PreprintDevelopmental Biology