Intermolecular Disulfide-Bond Formation In Human FICD Modulates The Activity Of The Hyperactive E234G Mutant
Raffaella Magnoni, Minttu S. Virolainen, Celeste Menuet Hackney, Cecilie L. Søltoft, Ana Paula Cordeiro, Yun Liu, Carsten Scavenius, Jan J. Enghild, Brian Christensen, James C. Paton, Adrienne W. Paton, Esben Skipper Sørensen, Lars Ellgaard
This paper shows that FICD's adenylyltransferase activity induces ER stress and that its disulfide-bond formation modulates its activity in the context of a hyperactive mutant.
bioRxiv · Apr 11, 2017 · PreprintMolecular Biology