Celeste Menuet Hackney

The paper shows that blocking protein quality control degradation stabilizes DHFR indel variants, suggesting a therapeutic approach for protein misfolding diseases.

This study characterizes conkazal-M1, a conotoxin from Conus magus, showing it acts as both a protease inhibitor and a neuroactive peptide.

The paper identifies BAG6 and RNF126 as key players in PQC degradation of non-native missense protein variants using CRISPR screens and VAMP-seq.

The paper uses structural bioinformatics to identify a new conotoxin family with a two-finger toxin fold, revealing evolutionary relationships among rapidly evolving genes.

This paper shows that FICD's adenylyltransferase activity induces ER stress and that its disulfide-bond formation modulates its activity in the context of a hyperactive mutant.