TOE1 influences canonical Wnt signalling in myeloid leukaemia cells through LEF-1 modulation and regulates the proliferation of haematopoietic cells through PAK2.
H. Park, O Sevim, M Wagstaff, A Goff, D Palmer, B Kim, K Heesom, Allison Blair, S Newbury, Ethan L. Morgan, BP Towler, Timothy J. T. Chevassut, RG Morgan
This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.
bioRxiv · Dec 15, 2025 · PreprintCancer Biology