Author

Fergus Hamilton

North Bristol NHS TrustORCID 0000-0002-9760-4059Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:GWAS summary statistics· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexander J. MentzeriD· 1 shared Amanda Yoon-Yee ChongiD· 1 shared Atsushi TakataiD· 1 shared Edward T Bulmore· 1 shared Gavin BandiD· 1 shared Golam Mohammed KhandakeriD· 1 shared Guillaume Butler‐LaporteiD· 1 shared Iona Y Milwood· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexander J. MentzerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NK Cell Activation as an Immune Mechanism in Depression: Insights from Single-Cell Multi-Omics

Matthew Boyton, Atsushi Takata, Fergus Hamilton, Robert Dantzer, Edward T Bulmore, Tom R. Gaunt, Golam Mohammed Khandaker

The paper identifies NK cell activation as a genetic and functional contributor to MDD susceptibility using single-cell transcriptomics and population genetics.

medRxiv · Oct 26, 2026 · PreprintGenetic & Genomic Medicine

Misclassification of heritable mortality undermines estimates of intrinsic life span heritability

Fergus Hamilton

The paper argues that classifying certain causes of death as non-genetic inflates heritability estimates of human lifespan.

medRxiv · Feb 27, 2026 · PreprintGenetic & Genomic Medicine

An accurate genetic colocalization method for the HLA locus

Guillaume Butler‐Laporte, Tianyuan Lu, Sam Morris, Wenmin Zhang, Gavin Band, Fergus Hamilton, Amanda Yoon-Yee Chong, Kuang Lin, Ruth Nanjala, John Brent Richards, Mei–Hsuan Lee, Ling Yang, Pang Yao, Liming Li, Zhengming Chen, , Alexander J. Mentzer

This paper introduces HLA-colocalization, a method for genetic colocalization at the HLA locus using HLA alleles, showing it identifies novel causal associations between viruses and autoimmune diseases.

medRxiv · Nov 5, 2024 · PreprintGenetic & Genomic Medicine

Phenotypic associations with the HMOX1 GT(n) promoter repeat in European populations

Fergus Hamilton, Ruth E. Mitchell, Peter Ghazal, Nicholas John Timpson

This study imputed HMOX1 GT(n) repeat length in European cohorts and found no significant phenotypic associations despite high imputation accuracy.

medRxiv · Apr 28, 2022 · PreprintGenetic & Genomic Medicine