Golam Mohammed Khandaker

NK Cell Activation as an Immune Mechanism in Depression: Insights from Single-Cell Multi-Omics

The paper identifies NK cell activation as a genetic and functional contributor to MDD susceptibility using single-cell transcriptomics and population genetics.

Genetic predisposition to loneliness increases schizophrenia and depression risk through inflammatory pathways: a Mendelian randomization study

This study uses Mendelian randomization to show loneliness causally increases schizophrenia and depression risk, partially mediated by inflammatory pathways.

Genome-wide association study of adolescent-onset depression

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK Biobank

The paper investigates the association between neurodevelopmental copy number variants (ND-CNVs) and increased risk of internalising and cardiometabolic multimorbidity using UK Biobank data.

Genomic insights into the comorbidity between type 2 diabetes and schizophrenia.

This study investigates the genetic relationship between type 2 diabetes and schizophrenia, finding no strong causal link but identifying shared genomic loci and biological pathways.

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort

This study investigates shared mechanisms between coronary heart disease and depression using UK Biobank data, finding that environmental factors and specific biomarkers like IL-6, CRP, and triglycerides are likely causal for depression.