This paper introduces HLA-colocalization, a method for genetic colocalization at the HLA locus using HLA alleles, showing it identifies novel causal associations between viruses and autoimmune diseases.

medRxiv · Nov 5, 2024 · PreprintGenetic & Genomic Medicine

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Alfred Pozarickij, Wei Gan, Kuang Lin, Robert Clarke, Zammy Fairhurst-Hunter, Masaru Koido, Masahiro Kanai, Yukinori Okada, Yoichiro Kamatani, Derrick Bennett, Huaidong Du, Yiping Chen, Ling Yang, Daniel Avery, Canqing Yu, , China Kadoorie Biobank Collaborative Group

This study identifies 128 BP-associated loci in Chinese adults through GWAS and shows causal links between BP traits and CVD using Mendelian randomisation.

Nature Communications · Jul 24, 2024Peer-reviewedGenetic & Genomic Medicine

Genetics of skeletal proportions in two different populations

Eric Bartell, Kuang Lin, Kristin Tsuo, Wei Gan, Sailaja Vedantam, Joanne B. Cole, John M. Baronas, Loïc Yengo, Eirini Marouli, Tiffany Amariuta, Zhengming Chen, Liming Li, China Kadoorie Biobank Collaborative Group, Nora E. Renthal, Christina M. Jacobsen, , Joel N. Hirschhorn

This study identifies 565 genetic loci associated with sitting height ratio (SHR) in two populations, finding distinct genetic signals from height and highlighting ancestry-specific effects.

bioRxiv · May 22, 2023 · PreprintGenetics

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Saori Sakaue, Marielisa Graff, Anders Ulrik Eliasen, Yunxuan Jiang, Sridharan Raghavan, Jenkai Miao, Joshua D. Arias, Ronen E. Mukamel, Cassandra Nichole Spracklen, Xianyong Yin, , Thomas Folkmann Hansen

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.

bioRxiv · Jan 7, 2022 · PreprintGenetics

Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations

Patrick Turley, Alicia R. Martin, Grant Goldman, Hui Li, Masahiro Kanai, Raymond Kenney Walters, Jonathan Jala, Kuang Lin, Iona Y. Millwood, Caitlin E. Carey, Duncan S. Palmer, Meghan L. Zacher, Elizabeth G. Atkinson, Zhengming Chen, Liming Li, , Benjamin M. Neale

This paper introduces MAMA, a method for multi-ancestry GWAS meta-analysis, which identifies novel genetic associations and improves power across populations.

bioRxiv · Apr 23, 2021 · PreprintGenomics

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

Nick R. G. Shrine, Anna L. Guyatt, Abdullah Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung S Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F. Reeve, Ma’en Obeidat, Jing Hua Zhao, , Andrew P. Morris

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

Nature Genetics · Feb 25, 2019Peer-reviewedGenomics