This study shows that genetic background and sex influence the indirect genetic effects of Epha4 in mice, revealing context-dependent social epistasis.

bioRxiv · Oct 1, 2026 · PreprintGenetics

The Hippo kinase LATS1 controls CTCF chromatin occupancy and the hormonal response of three-dimensionally grown breast cancer cells

Julieta Ramírez-Cuéllar, Roberto Ferrari, Rosario T. Sanz, Marta Valverde-Santiago, Ana Silvina Nacht, David Castillo, François Le Dily, Maria Victoria Neguembor, Marco Malatesta, Marc A. Martı́-Renom, Miguel Beato, Guillermo Pablo Vicent

This study shows that 3D culture of breast cancer cells alters chromatin structure and gene expression, with LATS1 kinase playing a key role in CTCF displacement and hormonal response.

bioRxiv · Nov 20, 2023 · PreprintGenomics

Hormone Control Regions mediate opposing steroid receptor-dependent genome organizations

François Le Dily, Enrique Vidal, Yasmina Cuartero, Javier Quilez, Ana Silvina Nacht, Guillermo Pablo Vicent, José Carbonell‐Caballero, Priyanka Sharma, José Luis Villanueva‐Cañas, Roberto Ferrari, Lara de Llobet, Gaetano Verde, Roni H. G. Wright, Miguel Beato

The paper identifies Hormone-Control Regions (HCRs) that organize genome structure and mediate opposing transcriptional responses to steroid hormones in breast cancer cells.

Genome Research · Jan 1, 2019Peer-reviewedGenomics