Fernanda Martins Marim

Integrated multiomic profiling of SCN2A loss-of-function reveals widespread molecular remodeling in patient hiPSC-derived neurons

This study investigates the molecular effects of SCN2A loss-of-function in patient-derived neurons, revealing NMD activation, isoform-specific dysregulation, and lncRNA network perturbations.

PI3Kγ pathway contributes to neuroinflammation and neuronal death induced by Zika virus infection

This study investigates the role of the PI3Kγ pathway in ZIKV-induced neuroinflammation and neuronal death, finding that its inhibition reduces viral replication and neuroinflammatory responses.

Microcephaly-like phenotype triggered by novel reassortant and prototypic Oropouche Virus strains in brain organoids

This study shows that Oropouche virus strains cause microcephaly-like effects in brain organoids by disrupting neural development and inducing cell death and apoptosis.

Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice

This study establishes a sex-dependent mouse model of post-COVID syndrome, showing neuropsychiatric and musculoskeletal complications in females that are prevented by ovariectomy.