Author

James D. McFadyen

Baker Heart and Diabetes InstituteORCID 0000-0002-9832-6871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aidan P. G. WalshiD· 1 shared Alex BobikiD· 1 shared Alexander Ruvantha PintoiD· 1 shared Ana C. Maluenda· 1 shared Anastasia Barbaro-WahliD· 1 shared Andrew James MurphyiD· 1 shared Angela Huang· 1 shared Anna M.D. WatsoniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

Aidan P. G. WalshORCID

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2 papers

Recent·Most cited

Autoimmune-like CD8⁺ T Cell Responses Drive Atherosclerotic Plaque Instability and Predict Cardiovascular Events

Jonathan Edward Noonan, Nicholas Borcherding, Sander W. van der Laan, Nicholas A. Gherardin, Moustafa I Morsy, Joshua I. Gray, Lisa Maria Domke, Anna M.D. Watson, Angela Huang, Anastasia Barbaro-Wahl, Shania A Prijaya, Marcel Michla, Zahra Elahi, Yilu Huang, Nalin H. Dayawansa, , K ouml nig Peter

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

bioRxiv · Apr 29, 2026 · PreprintImmunology

A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA (BNT162b2/mRNA-1273) and adenovirus vectored vaccines (ChAdOx1-S) after the first, second and third doses

Feargal J. Ryan, Todd S. Norton, Conor McCafferty, Stephen J. Blake, Natalie E. Stevens, Jane James, Georgina L. Eden, Yee C. Tee, Saoirse C. Benson, Makutiro Ghislain Masavuli, Arthur Eng Lip Yeow, Arunasingam Abayasingam, David Agapiou, Hannah Stevens, Jana Zecha, , David John Lynn

This study compares innate and adaptive immune responses to two COVID-19 vaccines in adults after multiple doses, identifying differences linked to antibody, T cell responses, and reactogenicity.

medRxiv · Sep 22, 2022 · PreprintGenetic & Genomic Medicine