Nicholas A. Gherardin

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

This study identifies γδ T cell infiltration in SCLC and shows their anti-tumor activity, suggesting they could be therapeutic targets.

The paper identifies a conserved TCR motif recognizing mycobacterial lipids presented by CD1c, showing higher frequencies in TB-endemic regions and providing a cryo-EM structure of the interaction.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study identifies a mechanism by which CD1c presents two lipids simultaneously, with bulky headgroups oriented sideways, enabling autoreactive TCR recognition.

This study identifies riboflavin catabolites that bind MR1, reduce its cell surface expression, and inhibit MAIT cell activation.