Author

Nikki L. Farnsworth

Colorado School of MinesORCID 0000-0002-9834-9168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Keifer Holcomb· 2 shared Ali Shilleh· 1 shared Amit SelaiD· 1 shared Andres Ocampo· 1 shared Ashton Fremin· 1 shared Austin Kratz· 1 shared Brisa PeñaiD· 1 shared Chelsea G. JohanseniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Keifer Holcomb

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Laminin-511 protects pancreatic β-cells from cytokine-induced death through integrin-mediated pro-survival signaling and modulation of protein kinase C δ

Christine El-Dirani, Meghana Hosahalli Shivananda Murthy, Keifer Holcomb, Gwendolyn Gutierrez, Riley Starzel, Brisa Peña, Daewon Park, Richard K.P. Benninger, Nikki L. Farnsworth

This study shows laminin-511 protects β-cells from cytokine-induced death by activating Akt signaling and reducing PKCδ activity through membrane DAG modulation.

bioRxiv · Aug 5, 2026 · PreprintCell Biology

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

Chelsea G. Johansen, Kenedee Lam, Nikki L. Farnsworth

This study shows stressed β-cells increase MMP-3, leading to loss of peri-islet ECM in T1D, suggesting MMP-3 inhibition could prevent islet death.

Frontiers in Endocrinology · Oct 10, 2025Peer-reviewedCell Biology

Peptide Coated Polycaprolactone-Benzalkonium Chloride Nanocapsules for Targeted Drug Delivery to the Pancreatic β-Cell

Jillian Collins, Jessie M. Barra, Keifer Holcomb, Andres Ocampo, Ashton Fremin, Austin Kratz, Jubril Olayinka Akolade, Julianna K. Hays, Ali Shilleh, Amit Sela, David J. Hodson, Johannes Broichhagen, Holger A. Russ, Nikki L. Farnsworth

This paper develops peptide-coated nanocapsules for targeted drug delivery to pancreatic β-cells, showing effective in vitro and in vivo targeting and cargo delivery.

ACS Applied Bio Materials · Sep 24, 2024Peer-reviewedBioengineering