Brisa Peña

This study develops sex- and disease-informed biomaterial design criteria from human lung tissue to create engineered hybrid-hydrogels that recapitulate mechanical and biochemical features of IPF.

This study shows that KLF4 in smooth muscle cell-derived progenitor cells drives AngII-induced cardiac inflammation and fibrosis by promoting a profibrotic phenotype.

This study shows laminin-511 protects β-cells from cytokine-induced death by activating Akt signaling and reducing PKCδ activity through membrane DAG modulation.

This study identifies the pericardium's origin from anterior mesothelial progenitors in zebrafish, distinct from the heart field, and links pericardial stiffness to pediatric cardiomyopathies.

This study identifies synergistic Notch-WNT signaling activation in pediatric dilated cardiomyopathy and shows its inhibition improves cardiac function.

The paper investigates how UTY modulates sex-specific methylation in male valvular fibroblasts in response to nanoscale extracellular matrix cues, promoting osteoblast-like cell phenotypes in aortic valve stenosis.