Author
University of North Carolina at Chapel HillORCID 0000-0002-9836-0068Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Jonathan R. Volpatti, Yukari Endo, Jessica J. Knox…·James J. Dowling
This study identifies drug modifiers for RYR1-related myopathy using a multi-species pipeline, finding p38 inhibition as a potential therapeutic strategy.
Megan J. Agajanian, Matthew P. Walker, Alison D. Axtman…·Michael B. Major
The paper identifies AAK1 as a negative regulator of WNT signaling through clathrin-mediated endocytosis of LRP6, validated using a new AAK1/BMP2K inhibitor.
Cunyu Zhang, Katrina L. Creech, William J. Zuercher, Timothy M. Willson
The paper develops a scalable synthesis of FICZ and shows light-dependent decomposition to a less active quinone, suggesting a role in sun exposure's biological effects.
Rafael M. Couñago, Alison D. Axtman, Stephen J. Capuzzi…·William J. Zuercher
The paper describes two compounds with minimal structural differences that show significant differential kinase activity, using x-ray crystallography and computational analysis to explain the selectivity.