Author

Jonathan M. Elkins

University of OxfordPrimary ORCID profile (0000-0003-2858-8929 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jonathan M. ElkinsiD2 papers · Cleveland Clinic

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Alison D. Axtman· 2 shared Carrow I. Wells· 2 shared David H. Drewry· 2 shared Opher Gileadi· 2 shared Rafael M. Couñago· 2 shared William J. ZuercheriD· 2 shared Adam Linekar· 1 shared Alessandra Mascarello· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCell Biology

Alison D. Axtman

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Author profile →

3 papers

Recent·Most cited

Precision Targeting of Troponin I Phosphorylation Prevents Diastolic Dysfunction while Preserving Systolic Performance

Ying‐Chi Chao, Debra J. McAndrew, David Revuelta, Rahul Yadav, Wan-Hua Hong, Jianshu Hu, Milda Folkmanaite, Edoardo Valli, Mariana Gee Olmedilla, Andreas Koschinski, Nicoletta Concetta Surdo, Jakub Tomek, Diederik W.D. Kuster, Helen V. Edwards, Connor M. Blair, , Manuela Zaccolo

This paper identifies a nanodomain mechanism regulating troponin I phosphorylation and demonstrates a peptide that selectively enhances relaxation without compromising systolic function in heart failure.

bioRxiv · Nov 18, 2025 · PreprintCell Biology

AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6

Megan J. Agajanian, Matthew P. Walker, Alison D. Axtman, Roberta R. Ruela-de-Sousa, Alex D. Rabinowitz, David M. Graham, Meagan Ryan, D. Stephen Serafin, James M. Bennett, Rafael M. Couñago, David H. Drewry, Jonathan M. Elkins, Carina Gileadi, Opher Gileadi, Paulo H. Godoi, , Michael B. Major

The paper identifies AAK1 as a negative regulator of WNT signaling through clathrin-mediated endocytosis of LRP6, validated using a new AAK1/BMP2K inhibitor.

bioRxiv · Feb 1, 2018 · PreprintCell Biology

Development of Narrow Spectrum ATP-competitive Kinase Inhibitors as Probes for BIKE and AAK1

Rafael M. Couñago, Alison D. Axtman, Stephen J. Capuzzi, Hátylas Azevedo, David H. Drewry, Jonathan M. Elkins, Opher Gileadi, Cristiano R. W. Guimarães, Alessandra Mascarello, Ricardo A. M. Serafim, Carrow I. Wells, Timothy M. Willson, William J. Zuercher

The paper describes two compounds with minimal structural differences that show significant differential kinase activity, using x-ray crystallography and computational analysis to explain the selectivity.

bioRxiv · Mar 2, 2017 · PreprintPharmacology & Toxicology