AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6
Megan J. Agajanian, Matthew P. Walker, Alison D. Axtman, Roberta R. Ruela-de-Sousa, Alex D. Rabinowitz, David M. Graham, Meagan Ryan, D. Stephen Serafin, James M. Bennett, Rafael M. Couñago, David H. Drewry, Jonathan M. Elkins, Carina Gileadi, Opher Gileadi, Paulo H. Godoi, , Michael B. Major
The paper identifies AAK1 as a negative regulator of WNT signaling through clathrin-mediated endocytosis of LRP6, validated using a new AAK1/BMP2K inhibitor.
bioRxiv · Feb 1, 2018 · PreprintCell Biology