Xiangze Zeng

Chemically programmed multistage morphogenesis in coacervate microdroplets

This paper demonstrates chemically programmed multistage morphogenesis in coacervate microdroplets using oxidation reactions and enzyme pathways to drive structural changes and fluorescent signaling.

Sequence-dependent molecular asymmetry and architecture define electric potential profiles of biomolecular condensates

This study shows molecular asymmetry and sequence architecture encode electric potential profiles in biomolecular condensates, revealing how charge distribution and protein structure influence interfacial potentials.

Simulating Thermoresponsive Behavior of Disordered Proteins with Temperature-Dependent Coarse-Grained Potentials Derived from Hydration Free Energies

This paper introduces TEA, a temperature-dependent coarse-grained model for simulating thermoresponsive behavior of disordered proteins, showing it accurately captures LCST and UCST transitions.

Coacervate Droplets as a Liquefier for the Solid-to-Liquid Transition of RNA Aggregates

This paper demonstrates that coacervate droplets can reverse solid RNA-peptide aggregates into functional liquid droplets, offering a method to manage pathological aggregation.

Asymmetry in hydrophobicity induces electric potential in non-charged protein condensates

This study shows that hydrophobic asymmetry in non-charged protein condensates creates electric potential gradients, enabling potential-dependent chemistry.

Higher-order Residue Interactions Encode Diversified Physical Properties of Biomolecular Condensates

This paper identifies higher-order residue interactions as key to modeling the physical properties of IDP condensates and shows how these interactions can reproduce experimental results.

Pentose Sugars Encode Sequence-Dependent DNA-RNA Segregation for Programmable Engineering of Multiphase Condensates

The paper shows that a single sugar difference between DNA and RNA drives phase segregation with cationic peptides, enabling programmable synthetic condensates that mimic nuclear compartments.

Backbone-mediated weakening of pairwise interactions enables percolation in peptide-based mimics of protein condensates

The paper shows how peptide backbones enhance pairwise interactions in dilute phases but weaken them in dense phases, enabling percolation in peptide-based mimics of protein condensates.

Sidechain chemistry-encoded solid/liquid phase transitions of condensates

This study investigates how alcohol-induced phase transitions in biomolecular condensates depend on sidechain chemistry and molecular interactions, revealing mechanisms for liquid-to-solid and solid-to-liquid transitions.