Sherida M. de Leeuw

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

This study investigates how APOE genotype, sex, and aging affect intracellular cholesterol and the endolysosomal system in mouse brains, revealing region-specific and sex-dependent changes in APOE4 mice.

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

This study shows APOE alleles E2, E3, and E4 differentially affect astrocyte metabolism, cholesterol handling, and inflammation in isogenic iPSC-derived cells, with E4 showing disease-relevant dysregulation.