Matthias Gunzer

This study shows that neutrophil phagocytic activity in S. aureus infection is driven by prior pathogen encounters rather than tissue dwell time.

This study shows that hyperlipidemia reduces the neuroprotective effects of MSC-derived extracellular vesicles, but DNase-I treatment restores their efficacy by rebalancing immune responses.

The paper identifies emperipolesis as a process where megakaryocytes transfer proteins to neutrophils, enhancing their immune function and migration.

This study shows that monocytes are essential for the neuroprotective effects of MSC-EVs in stroke, as their depletion negates these benefits and leads to immune system dysregulation.

This study identifies PmrB as an oxidative stress sensor in A. baumannii that confers virulence through response memory, enhancing survival during infection.

The paper shows that CD4 T cell memory is enhanced when antigens are presented by intestinal epithelial cells rather than bacterial proteins.

This study shows that neutralizing extracellular histones reduces secondary brain injury and improves recovery after ischemic stroke complicated by pneumonia.

This study identifies REG3β as a factor that removes aged neutrophils after myocardial infarction, promoting inflammation resolution and cardiac repair.

This study identifies tumor-initiating cells that modulate neutrophil plasticity to create a protective niche, preventing immunotherapy effectiveness.

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.

VesselExpress automates 3D blood vasculature analysis in LSFM data, enabling rapid and unbiased quantification of vascular parameters across multiple organs.

The paper shows that antidepressants inhibit acid sphingomyelinase, reducing brain damage after ischemia/reperfusion and promoting angiogenesis via exosome release.

This study shows that experimental stroke in mice increases ACE2 expression and inflammation in the lungs, potentially explaining why stroke patients are at higher risk for severe SARS-CoV-2 infections.

This paper presents standardization efforts for cell migration data to improve data sharing and analysis.