Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele.
Anand Chellappan Reghuvaran, Ashwani Kumar, Qisheng Lin, Nallakandi Rajeevan, Zeguo Sun, Hongmei Shi, Gabriel Barsotti, E. M. Tanvir, John F. Pell, Sudhir Perincheri, Chengguo Wei, Marina Planoutene, Anne Eichmann, Valeria R. Mas, Weijia Zhang, , Madhav C. Menon
This study identifies the Shroom3 ASD2-domain as critical for profibrotic function in CKD through ROCK activation, showing motif-specific roles in renal fibrosis and albuminuria.
bioRxiv · Nov 22, 2024 · PreprintSystems Biology