Author

William W. Bachovchin

Tufts UniversityORCID 0000-0002-9926-7244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alfred Lewis GoldbergiD· 1 shared Andrew L. Coppage· 1 shared Angelina J. Lay· 1 shared Belinda Yau· 1 shared Bertrand D. E. RaynaliD· 1 shared Denise Ming Tse Yu· 1 shared Diego F. GautoiD· 1 shared Dmitry A. SemchonokiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Alfred Lewis GoldbergORCID

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2 papers

Recent·Most cited

Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases.

Katharina Weinhäupl, Tatos N. Akopian, Dmitry A. Semchonok, Olga Krandor, Rocío Arranz, M. Teresa Bueno-Carrasco, Marcos Gragera, Maelenn Chevreuil, Bertrand D. E. Raynal, Samuel Zinga, Yuxin Liu, Jack Hung-Sen Lai, Wengen Wu, William W. Bachovchin, Diego F. Gauto, , Hugo Fraga

This study identifies trehalose as an activator of ClpC1P1P2 and ClpXP1P2 protease complexes in Mycobacterium tuberculosis, revealing a new mechanism for in vivo activation without the need for peptide activators.

Cell Reports · May 30, 2026Peer-reviewedBiochemistry

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

Sumaiya Chowdhury, Sunmi Song, Hui Emma Zhang, Xin Maggie Wang, Margaret G. Gall, Denise Ming Tse Yu, Angelina J. Lay, Michelle Sui Wen Xiang, Kathryn A. Evans, Stefanie Wetzel, Yolanda Liu, Belinda Yau, Andrew L. Coppage, Lisa Lo, Rebecca A. Stokes, , Mark D. Gorrell

This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.

bioRxiv · Nov 4, 2018 · PreprintPathology