Marcos Gragera

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

This study identifies trehalose as an activator of ClpC1P1P2 and ClpXP1P2 protease complexes in Mycobacterium tuberculosis, revealing a new mechanism for in vivo activation without the need for peptide activators.

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

The paper investigates using p-values to estimate the number of distinguishable classes in cryoEM data by testing if classifications differ from random partitions.