Evolutionary fingerprint in rodent PD1 confers weakened activity and enhanced tumor immunity compared to human PD1
Takeya Masubuchi, Lin Chen, Nimi Marcel, George A. Wen, Christine Caron, Jibin Zhang, Yunlong Zhao, Gerald P. Morris, Xu Chen, Stephen Μ. Hedrick, Li‐Fan Lu, Chuan Wu, Zhengting Zou, Jack D. Bui, Enfu Hui
This study compares human and rodent PD1 proteins, finding rodent PD1 has weaker inhibitory activity and stronger tumor immunity due to evolutionary changes in Shp2 recruitment.
Science Immunology · Jan 3, 2025Peer-reviewedImmunology