Author

Stephen Μ. Hedrick

University of California San DiegoORCID 0000-0002-6345-8751Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:genome assembly· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander J. WeitzeliD· 1 shared Ceri J. WeberiD· 1 shared Christine Caron· 1 shared Chuan WuiD· 1 shared Enfu HuiiD· 1 shared Ethan BieriD· 1 shared George A. WeniD· 1 shared Gerald P. MorrisiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Alexander J. WeitzelORCID

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2 papers

Recent·Most cited

Evolutionary fingerprint in rodent PD1 confers weakened activity and enhanced tumor immunity compared to human PD1

Takeya Masubuchi, Lin Chen, Nimi Marcel, George A. Wen, Christine Caron, Jibin Zhang, Yunlong Zhao, Gerald P. Morris, Xu Chen, Stephen Μ. Hedrick, Li‐Fan Lu, Chuan Wu, Zhengting Zou, Jack D. Bui, Enfu Hui

This study compares human and rodent PD1 proteins, finding rodent PD1 has weaker inhibitory activity and stronger tumor immunity due to evolutionary changes in Shp2 recruitment.

Science Immunology · Jan 3, 2025Peer-reviewedImmunology

Meiotic Cas9 expression mediates genotype conversion in the male and female mouse germline

Alexander J. Weitzel, Hannah A. Grunwald, Ceri J. Weber, Rimma Levina, Valentino Matteo Gantz, Stephen Μ. Hedrick, Ethan Bier, Kimberly L. Cooper

This study shows that meiotic Cas9 expression can mediate genotype conversion in both male and female mouse germlines, but low Cas9 levels limit efficiency.

PLoS Biology · Dec 23, 2021Peer-reviewedGenetics