Author

Danielle R. Rux

Children's Hospital of PhiladelphiaORCID 0000-0002-9952-4474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Abby L. BrumwelliD· 1 shared Antony K. SorialiD· 1 shared Biao HaniD· 1 shared Courtney Cortese· 1 shared David Alan YoungiD· 1 shared Eiki KoyamaiD· 1 shared Euan McDonnelliD· 1 shared Jamie SouliD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenetic & Genomic Medicine

Abby L. BrumwellORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Epigenetic mechanisms of osteoarthritis risk in human skeletal development

Euan McDonnell, Sarah E. Orr, Matthew J. Barter, Danielle R. Rux, Abby L. Brumwell, Nicola Wrobel, Lee Murphy, Lynne M. Overman, Antony K. Sorial, David Alan Young, Jamie Soul, Sarah J. Rice

This study quantifies DNA methylation changes during human articular cartilage development and identifies epigenomic mediators of osteoarthritis risk in prenatal joint tissues.

The American Journal of Human Genetics · Nov 22, 2024Peer-reviewedGenetic & Genomic Medicine

Primary cilia drive postnatal tidemark patterning in articular cartilage by coordinating responses to Indian Hedgehog and mechanical load

Danielle R. Rux, Kimberly Helbig, Biao Han, Courtney Cortese, Eiki Koyama, Lin Han B, Maurizio Pacifici

This study shows primary cilia regulate postnatal articular cartilage organization by coordinating Indian Hedgehog signaling and mechanical load responses, affecting tidemark patterning and matrix composition.

bioRxiv · Jul 4, 2021 · PreprintDevelopmental Biology