Eiki Koyama

Impaired loading following denervation elicits dynamic, differential growth trajectories of musculoskeletal tissues

This study shows that denervation in neonatal mice impairs musculoskeletal growth, altering cell proliferation and mechanotransduction gene programs in tendons and muscles.

Intrinsic and growth-mediated cell and matrix specialization during meniscus tissue assembly

This study tracks meniscus maturation in mice, showing that specialized cellular and matrix features emerge before birth and are refined during postnatal growth.

Primary cilia drive postnatal tidemark patterning in articular cartilage by coordinating responses to Indian Hedgehog and mechanical load

This study shows primary cilia regulate postnatal articular cartilage organization by coordinating Indian Hedgehog signaling and mechanical load responses, affecting tidemark patterning and matrix composition.

Identification of Gli1 as a progenitor cell marker for meniscus development and injury repair

This study identifies Gli1+ cells as a progenitor population in meniscus development and injury repair, showing their therapeutic potential in preventing osteoarthritis.