Author

Lynne M. Overman

Centre for Life

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetic & Genomic Medicine· 1 Genetics· 1

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:clustering· 1

Frequent Co-Authors

Steven LisgoiD· 3 shared Abby L. BrumwelliD· 1 shared Ahlam AlqahtaniiD· 1 shared Alex LaudeiD· 1 shared Alexander B. RosenbergiD· 1 shared Andrew E. TimmsiD· 1 shared Antony K. SorialiD· 1 shared Belén Lorente-GaldósiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersDevelopmental Biology

Steven LisgoORCID

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Author profile →

4 papers

Recent·Most cited

Epigenetic mechanisms of osteoarthritis risk in human skeletal development

Euan McDonnell, Sarah E. Orr, Matthew J. Barter, Danielle R. Rux, Abby L. Brumwell, Nicola Wrobel, Lee Murphy, Lynne M. Overman, Antony K. Sorial, David Alan Young, Jamie Soul, Sarah J. Rice

This study quantifies DNA methylation changes during human articular cartilage development and identifies epigenomic mediators of osteoarthritis risk in prenatal joint tissues.

The American Journal of Human Genetics · Nov 22, 2024Peer-reviewedGenetic & Genomic Medicine

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

Rachel A. Queen, Moira Crosier, Lorraine Eley, Janet M. Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne M. Overman, Hannah Soetjoadi, Richard Baldock, Jonathan M Coxhead, Veronika Boczonadi, Alex Laude, Simon Cockell, , Deborah J. Henderson

This study uses spatial transcriptomics to analyze human embryonic arterial valves, identifying novel genes and pathways involved in valve development and highlighting limitations in current genomic databases.

PLoS Genetics · Nov 27, 2023Peer-reviewedDevelopmental Biology

Spatial and single-cell transcriptional landscape of human cerebellar development

Kimberly A. Aldinger, Zachary Thomson, Ian G. Phelps, Parthiv Haldipur, Mei Deng, Andrew E. Timms, Matthew Hirano, Gabriel Santpere, Charles M. Roco, Alexander B. Rosenberg, Belén Lorente-Galdós, Forrest O. Gulden, Diana R. O’Day, Lynne M. Overman, Steven Lisgo, , Kathleen J. Millen

This study maps the spatial and single-cell transcriptional landscape of human cerebellar development, revealing cell-type-specific gene expression and implications for neurological disorders.

Nature Neuroscience · Jun 17, 2021Peer-reviewedDevelopmental Biology

Embryonic and foetal expression patterns of the ciliopathy gene CEP164

Laura Alice Devlin, Simon A. Ramsbottom, Lynne M. Overman, Steven Lisgo, Gavin John Clowry, Elisa Molinari, Laura Powell, CG Miles, John Andrew Sayer

The paper identifies widespread and defined expression patterns of CEP164 in human embryonic and foetal tissues, with similar patterns observed in mice, suggesting conserved developmental roles contributing to multi-system disease.

PLoS ONE · Jan 28, 2020Peer-reviewedGenetics