Sarah E. Orr

Single-cell proteomics resolves major cell populations and protein-defined chondrocyte states in the adult human osteoarthritic joint

This study uses single-cell proteomics to identify protein-defined chondrocyte states and other cell populations in human osteoarthritic joints, complementing single-cell transcriptomics.

Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.

Epigenetic mechanisms of osteoarthritis risk in human skeletal development

This study quantifies DNA methylation changes during human articular cartilage development and identifies epigenomic mediators of osteoarthritis risk in prenatal joint tissues.