Lin Han B

This study shows that denervation in neonatal mice impairs musculoskeletal growth, altering cell proliferation and mechanotransduction gene programs in tendons and muscles.

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

This study identifies decorin-mediated extracellular matrix stabilization as a key factor in maintaining cartilage integrity during aging, showing its role in preventing age-associated osteoarthritis.

This study shows decorin strengthens collagen II-aggrecan integration in cartilage matrix, reducing aggrecan loss and supporting its therapeutic potential for osteoarthritis.

This paper introduces a click chemistry-based method to quantify ECM turnover, validated for drug screening and regenerative medicine applications.

This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.

This study shows that ECM physical properties, not chemistry, determine cancer cell morphology in 3D hydrogels, with cells adopting elongated or clustered states based on matrix stiffness.

This study uses photo-crosslinking to induce early fibrotic changes in ex vivo tissue, showing how matrix stiffening affects cell behavior and fibrosis progression.

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

This study examines how injury size affects immune cell dynamics in muscle repair, finding early macrophage dysfunction and increased neutrophils in fibrotic outcomes.

This study tracks meniscus maturation in mice, showing that specialized cellular and matrix features emerge before birth and are refined during postnatal growth.

This study shows primary cilia regulate postnatal articular cartilage organization by coordinating Indian Hedgehog signaling and mechanical load responses, affecting tidemark patterning and matrix composition.

This study identifies Gli1+ cells as a progenitor population in meniscus development and injury repair, showing their therapeutic potential in preventing osteoarthritis.