Author

William T. O’Brien

Monash UniversityORCID 0000-0002-9966-0134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Ella RowsthorniD· 2 shared Ian H. HardingiD· 2 shared Katherine H. FranksiD· 2 shared Lucy E. VivashiD· 2 shared Marina G. CavuotoiD· 2 shared Matthew Paul PaseiD· 2 shared Meng LawiD· 2 shared Ming Ann SimiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Ella RowsthornORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health

Ella Rowsthorn, Ming Ann Sim, William T. O’Brien, Stuart J. McDonald, Katherine H. Franks, Benjamin Sinclair, Trevor T.‐J. Chong, Stephanie R Yiallourou, Marina G. Cavuoto, Lucy E. Vivash, Terence John O'Brien, Xingfeng Shao, Danny J.J. Wang, Meng Law, Ian H. Harding, Matthew Paul Pase

The paper uses factor analysis on multimodal biomarkers to identify latent constructs of brain health, finding five distinct constructs associated with age and cognitive function.

GeroScience · Jul 8, 2025Peer-reviewedNeuroscience

Plasma pTau-217 Correlates with Brain Atrophy, Cognition, and CSF Biomarkers in a Cognitively Healthy Community Cohort

Ming Ann Sim, Ella Rowsthorn, William T. O’Brien, Mujun Sun, Lachlan Cribb, Katherine H. Franks, Stuart J. McDonald, Stephanie R Yiallourou, Marina G. Cavuoto, Ian H. Harding, Trevor T.‐J. Chong, Meng Law, Terence John O'Brien, Lucy E. Vivash, Matthew Paul Pase

This study finds plasma pTau-217 correlates with cognition and brain atrophy in cognitively healthy older adults and strongly correlates with its CSF counterpart.

bioRxiv · Apr 30, 2025 · PreprintNeuroscience

Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome

Brigitta B. Gundersen, William T. O’Brien, Melanie D. Schaffler, Maria N. Schultz, Tatsuya Tsukahara, Sandra Martín Lorenzo, Valérie Nalesso, Alice Luo Clayton, Ted G. Abel, Jacqueline N. Crawley, Sandeep Robert Datta, Yann Hérault

Experiments across four laboratories found that arbaclofen rescued cognitive deficits in mouse models of 16p11.2 deletion, without sedation or significant off-target behavioral effects.

bioRxiv · May 1, 2023 · PreprintNeuroscience