Yamini Dalal

This study shows that H2B variants, particularly H2B1O, alter chromatin accessibility and induce EMT in breast cancer, suggesting their role as onco-histones and potential therapeutic targets.

MetaChrome automates metaphase chromosome analysis using deep learning, improving segmentation accuracy and enabling colocalization analysis of FISH signals and proteins.

The paper investigates how an oncogenic lncRNA transgene affects epigenetic memory at a naive chromosomal locus, showing that epigenetic silencing can reverse ectopic CENP-A deposition over time.

This study shows H1.5 interacts with CENP-A nucleosomes at centromeres, and its depletion causes centromere dysfunction and mitotic defects in human cells.

This study shows that centromere inactivation during aging in human cells can be reversed by inhibiting p53 and LSD1/KDM1A, restoring centromeric proteins and transcripts.

This study shows that H2B variants alter chromatin structure and oncogenic gene expression, suggesting they may be early cancer biomarkers and therapeutic targets.

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.

This study identifies CENP-A associated lncRNAs transcribed from centromeres in early G1 phase and shows their functional role in chromosome segregation.